Incidental Solid Pseudopapillary Neoplasm of the Pancreas in a Young Female: Case Report and Literature Review
Chaymaa Khyat *
Department of Functional Digestive Explorations, Ibn Sina University Hospital, Mohammed V University, Rabat, Morocco.
Mohammed Reda El Hassouni
Department of Surgical Oncology, National Institute of Oncology, Mohammed V Univeristy, Rabat, Morocco and Mohammed Vth University in Rabat, Morocco, Medical School, Surgery Department ‘A’, Ibn Sina Hospital Rabat, Morocco.
Mouna Salihoun
Department of Functional Digestive Explorations, Ibn Sina University Hospital, Mohammed V University, Rabat, Morocco.
Ilham Serraj
Department of Functional Digestive Explorations, Ibn Sina University Hospital, Mohammed V University, Rabat, Morocco.
Hadj Omar El Malki
Mohammed Vth University in Rabat, Morocco, Medical School, Surgery Department ‘A’, Ibn Sina Hospital Rabat, Morocco and Clinical Research and Epidemiological Laboratory, Mohammed V University in Rabat, Morocco, Medical School, Rabat, Morocco.
Nawal Kabbaj
Department of Functional Digestive Explorations, Ibn Sina University Hospital, Mohammed V University, Rabat, Morocco.
*Author to whom correspondence should be addressed.
Abstract
Introduction: Solid pseudopapillary neoplasm (SPN) of the pancreas is a rare epithelial tumor with low malignant potential, predominantly affecting young women, and is often discovered incidentally.
Presentation of Case: We report the case of a 21-year-old female with no significant medical history who presented with one-month secondary amenorrhea. An abdominal ultrasound revealed an incidental pancreatic mass. Contrast-enhanced computed tomography and magnetic resonance imaging demonstrated a well-circumscribed lesion in the pancreatic body, without vascular invasion or metastatic spread. Endoscopic ultrasound-guided biopsy revealed solid and pseudopapillary architecture, and immunohistochemistry confirmed SPN. After multidisciplinary discussion, the patient underwent central pancreatectomy. Histopathological examination confirmed SPN staged pT2 Nx. The postoperative course was uneventful.
Conclusion: SPN should be considered in the differential diagnosis of pancreatic lesions in young women, even when incidentally discovered. In general, complete surgical resection, including parenchyma-sparing procedures such as central pancreatectomy, is associated with excellent long-term outcomes and prognosis in the vast majority of cases.
Keywords: Solid pseudopapillary neoplasm, pancreas tumors, endoscopic ultrasound-guided biopsy, incidental pancreatic lesion